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Precautions

Do NOT use Vytorin if:

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• you consider an HIV protease inhibitor (eg, nelfinavir, lopinavir, ritonavir), itraconazole, ketoconazole, a macrolide or ketolide antibiotic (eg, clarithromycin, erythromycin, troleandomycin), mibefradil, or nefazodone

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Contact a medical expert or physician straight away if these apply to you.

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Some health conditions may communicate with Vytorin. Tell a medical expert or pharmacist if you have any health concerns, particularly if any of the following affect you:

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Some medicines may talk with Vytorin. Tell your doctor if you are taking every other medicines, especially any with the following:

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• Amiodarone, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, itraconazole, ketoconazole), cyclosporine, danazol, delavirdine, diltiazem, fibrates (eg, clofibrate, fenofibrate), fluconazole, gemfibrozil, HIV protease inhibitors (eg, ritonavir), imatinib, macrolide antibiotics (eg, erythromycin), macrolide immunosuppressives (eg, tacrolimus), mibefradil, nefazodone, niacin, nicotinic acid, streptogramins, telithromycin, verapamil, or voriconazole because side effects, such as muscle pain, may occur

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This is probably not a complete list of all interactions which could occur. Ask your health care provider if Vytorin may interact with other medicines that you just take. Check with your physician before you start, stop, or change the dose from a medicine.

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Important safety information:

• Vytorin could potentially cause dizziness, drowsiness, or modifications in vision. These effects could possibly be worse if you get it with alcohol or certain medicines. Use Vytorin with caution. Do not drive or perform other possible unsafe tasks unless you understand how you respond to it.

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• Proper dental care is important while you are taking Vytorin. Brush and floss your teeth and go to the dentist regularly.

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• Vytorin may harm your liver. Your risk could possibly be greater in the event you consume alcohol while you are using Vytorin. Talk to your doctor before you take Vytorin or another fever reducers in the event you drink more than 3 drinks with alcohol daily.

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• Vytorin should be in combination with extreme caution in youngsters younger ten years; safety and effectiveness over these children have not been confirmed.

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• Pregnancy and breast-feeding: Do not use Vytorin in case you are pregnant. Avoid getting pregnant if you are taking it. If you think you could possibly be pregnant, contact your medical professional immediately. It is not known if Vytorin is located in breast milk. Do not breastfeed while taking Vytorin.