Immune System: hypersensitivity reaction, rash with or without pruritus;
Hematologic: leukopenia; hemolytic anemia;
Though rare, anaphylactoid reactions have been reported with metaxalone.
Skelaxin may boost the effects of alcohol and other CNS depressants.
Metaxalone needs to be administered with great care to patients with pre-existing liver damage. Serial liver function studies needs to be performed of these patients.
Taking Skelaxin with food may enhance general CNS depression; elderly patients may be especially vunerable to this CNS effect.
The carcinogenic potential of metaxalone has not been determined.
Metaxalone tablets mustn't be employed in girls that are or can be pregnant and particularly during early pregnancy unless, in the judgement from the physician, the opportunity benefits outweigh the possible hazards.
It just isn't known whether this drug is secreted in human milk. As a general rule, nursing shouldn't be undertaken while a patient is on the drug since many prescription medication is excreted in human milk.
Safety and effectiveness in kids of 12 years and below have not been established.
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