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Precautions

Do NOT use Clozaril if:

• you're allergic to your ingredient in Clozaril
• you might have bone marrow problems, other blood cell problems, or possibly a good reputation for blood problems a result of Clozaril
• you might have uncontrolled seizures (eg, epilepsy) or loss of bowel muscle movement (paralytic ileus)
• you have severe drowsiness
• you consider other medicines that may cause blood problems. Ask your doctor in case you are unsure if all of your medicines might cause blood problems.

Contact your doctor or health care provider without delay if all of these connect with you.

Some health conditions may talk with Clozaril. Tell a medical expert or pharmacist for those who have any medical ailments, particularly when any of the following affect you:

• should you be pregnant, planning to conceive, or are breast-feeding
• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, or any other substances
• for those who have a good reputation for blood clots, blood problems, high blood cholesterol, cardiovascular disease, or lung or breathing problems
• for those who have a history of the enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel obstruction; or dementia
• in case you have poor health, diabetes, or perhaps a family member with diabetes, or you happen to be very overweight
• if you have decreased activity of enzymes that metabolize certain medicines.

Some medicines may interact with Clozaril. Tell your doctor if you take some other medicines, especially any of the following:

• Benzodiazepines (eg, lorazepam) and other medicines for mental or mood problems for the reason that chance of heart or breathing problems might be increased
• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they might increase the chance of Clozaril's unwanted effects
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin since they may decrease Clozaril's effectiveness
• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or hypertension, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) because the risk of their negative effects could possibly be increased by Clozaril.

This is probably not an entire list of all interactions that could occur. Ask your medical provider if Clozaril may interact with other medicines which you take. Check together with your physician prior to starting, stop, or customize the dose associated with a medicine.

Important safety information:

• Clozaril may cause drowsiness, dizziness, or lightheadedness. These effects could be worse if you go on it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you respond to it.
• Do not use alcohol or medicines that could cause drowsiness (eg, sleep aids, muscle relaxers) when you taking Clozaril. It may improve their effects. Ask your friendly phamacist if you have questions about which medicines may cause drowsiness.
• Clozaril may cause dizziness, lightheadedness, or fainting; alcohol, warm weather, exercise, or fever may increase these effects. To prevent them, crunch or stand slowly, especially inside the morning. Sit or lay down on the first sign of any of these effects.
• Clozaril may lower the ability of the body to fight infection. Avoid exposure to people who have colds or infections. Tell your medical professional right away you may notice any indications of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background could be at greater risk of developing blood difficulty with Clozaril.
• If you've got a good seizures, you could suddenly lose conscious whilst you are taking Clozaril. Avoid activities through which decrease of conscious may be dangerous to you personally kinds (eg, driving, swimming, climbing, operating machinery).
• Clozaril may lift up your blood sugar. High blood sugar levels may make you feel confused, drowsy, or thirsty. It can also cause you to flush, breathe faster, or use a fruit-like breath odor. If these symptoms occur, tell a medical expert straight away.
• Avoid refreshments an excellent source of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell your medical professional or dentist that you simply take Clozaril. It could influence the medical or dental care, emergency care, or surgery you could receive.
• Neuroleptic malignant syndrome (NMS) can be a possibly fatal syndrome that can be caused by Clozaril. Symptoms can sometimes include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact a medical expert immediately when you have these symptoms.
• Some patients taking Clozaril may develop muscle movements they cannot control. This is prone to occur in elderly patients, especially women. The chance that could happen or that it'll become permanent is greater in those having Clozaril in high doses or a long time. Muscle problems can also occur after short-term treatment with low doses. Tell your physician simultaneously if you have muscle problems together with your tongue, face, mouth, jaw (eg, tongue herniated, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, could possibly be performed to observe your progress or pay attention to negative effects. Be sure to keep all doctor and lab appointments.
• Use Clozaril with caution inside elderly; they could possibly be more responsive to its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.
• Clozaril needs to be used in combination with extreme care in children; safety and effectiveness in kids weren't determined.
• Pregnancy and breast-feeding: If you get pregnant, contact your doctor. You will need to discuss the advantages and perils of using Clozaril while you are pregnant. It is not known if Clozaril is situated in breast milk. Do not breastfeed while taking Clozaril.