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See also Warning section.

This medicine is used to treat mental/mood that is certain (schizophrenia, schizoaffective disorders). Clozapine is a medication that is psychiatricanti-psychotic type) that works by assisting to restore the balance of certain natural substances (neurotransmitters) within the brain.

Clozapine decreases hallucinations and helps in avoiding committing suicide in individuals who tend to try to harm themselves. It helps one to think more clearly and positively about yourself, feel less nervous, and indulge in everyday life.

Utilizing Clozaril

If you are using the liquid form of the medication, read the Patient Ideas Leaflet if available from your pharmacist before you begin taking clozapine and every time you get a refill. When you yourself have any relevant questions, ask your doctor or pharmacist.

Simply take this medication by mouth with or without food, as directed by your doctor. If you're taking the tablets that dissolve in the mouth, remove each tablet carefully from the blister pack immediately before taking your dose. Allow the tablets to dissolve on your tongue and swallow. You do not need to take the dissolving tablets with water. Discard any dissolving tablets that have been formerly confronted with air due to opened/damaged packaging. Do not save them for your next dose.

If you work with the liquid form of this medication, shake the bottle well for 10 seconds before each use. Carefully measure the dose using a special measuring device/spoon. Don't use a household spoon because may very well not obtain the correct dose.

You will need to begin taking this drug at a low dose, increasing your dose slowly, to lessen side effects such as dizziness, drowsiness and seizures. Follow your doctor's instructions exactly. Your dosage is based on your medical condition and response to therapy. Since clozapine can cause a decrease in white blood cells, you shall need certainly to get blood tests done regularly as directed. Be sure to keep all appointments for these laboratory tests. (See also Notes section.)

You were on (see Missed Dose section) if you miss your doses for longer than a day or two, consult your doctor for a new schedule to get back to the dose. Use this medication regularly in order to get the most benefit from it. To help you keep in mind, utilize it at the time( that is same) each day.

Do not stop taking clozapine without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Also, you might experience symptoms such as severe sweating, headache, nausea, vomiting, and diarrhoea. To prevent these symptoms while you are stopping treatment with this medication, your doctor may reduce your dose slowly. Consult your pharmacist or doctor for more details. Report any new or symptoms that are worsening away.

It might take many weeks ahead of the full benefit of this drug takes effect. Inform your doctor if the condition persists or worsens.

Side Effects

See also Warning section.

Drooling, drowsiness, dizziness, headache, shaking (tremor), vision problems (e.g., blurred vision), weight gain, and constipation may occur. Many of these effects (especially drowsiness) lessen as your body gets used to the medication. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

To stop constipation, keep a diet adequate in fiber, drink plenty of water, and workout. If you then become constipated while using this medication, check with your pharmacist for help in selecting a laxative (age.g., stimulant-type with stool softener).

Remember that your doctor has recommended this medication she has judged that the benefit to you is greater than the risk of adverse effects because he or. Many people using this medication do not have adverse that is serious.

This medication may rarely make your blood sugar level rise, which can cause or worsen diabetes. Rarely, very serious conditions such as diabetic coma may occur. Tell your doctor straight away if you develop symptoms of high blood glucose, such as increased thirst and urination. In the event that you already have diabetic issues, make sure to check your blood sugars regularly. Your medical professional may have to adjust your diabetes medication, exercise program, or diet.

This medication could also cause significant weight gain and a growth in your cholesterol (or triglyceride) levels. These effects, along side diabetic issues, may increase your risk for developing heart disease. Discuss the risks and advantages of treatment with your doctor.

Tell your doctor right away when you have any serious side effects, including: facial/muscle twitching, seizures, uncontrollable movements.

Get help that is medical away if you have any extremely severe part effects, including: severe dizziness, fainting, mental/mood changes, difficulty breathing with workout, sudden weakness, pain/redness/swelling of the arms/legs, persistent nausea/vomiting, stomach/abdominal pain, yellowing of eyes/skin.

This medication may seldom cause a very condition that is serious neuroleptic malignant syndrome (NMS). Get help that is medical away if you have associated with the following symptoms: temperature, muscle stiffness/pain/tenderness/weakness, severe tiredness, serious confusion, sweating, fast/irregular heartbeat, dark urine, change in the amount of urine.

A very severe reaction that is allergic this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may consist of: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is simply not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the United States -

Call your medical practitioner for medical advice about part results. You may report side effects to Food And Drug Administration at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about adverse effects. You'll report adverse effects to Health Canada at 1-866-234-2345.


See also Warning and adverse Effects parts.

Before using clozapine, tell your physician or pharmacist in the event that you are allergic to it or if you have any other allergies. This product may contain ingredients that are inactive which may cause allergy symptoms or other problems. Speak to your pharmacist for more information.

Before using this medicine, tell your medical practitioner or pharmacist your medical history, especially of: history of blood disorders (such as for example leukemia, low blood that is white count), bowel problems (such as paralytic ileus, irritable bowel problem ), difficulty in breathing, diabetes/family history of diabetes, high cholesterol/triglyceride levels, glaucoma, heart problems, renal problems, liver problems, obesity/family history of obesity, seizures, difficulty urinating (such as prostate problems).

Clozapine may cause an ailment that affects the center rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as for instance serious dizziness, fainting) that need medical attention appropriate away.

The risk of QT prolongation may be increased if you have certain conditions that are medical are taking other drugs that will impact one's heart rhythm. Before making use of clozapine, tell your medical professional or pharmacist of all the drugs you take and when you yourself have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation within the EKG), genealogy and family history of certain heart problems (QT prolongation in the EKG, unexpected cardiac death).

Low levels of potassium or magnesium in the blood may increase your risk also of QT prolongation. This risk may increase if you have conditions such as severe sweating, diarrhea, or vomiting if you use certain drugs (such as diuretics/"water pills") or. Talk to your doctor about using clozapine safely.

This drug can make you dizzy or drowsy or cause vision that is blurred. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Tell your doctor because you may be at a higher risk for a drop in your white blood cells if you are a descendent of Ashkenazi Jews.

Before having surgery, tell your dentist or doctor that you will be applying this medicine.

Liquid items or dissolving tablets may contain sugar and/or aspartame. Liquid products may contain alcohol also. Caution is advised you to limit/avoid these substances in your diet if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires. Ask your doctor or pharmacist about using this product safely.

Older adults may be more sensitive to the relative side effects of this drug, specially constipation, dizziness, and QT prolongation (see above). Dizziness can increase the risk of falling.

During maternity, this medicine should be used only when plainly needed. Babies born to mothers who have used this medication during the last 3 months of pregnancy may rarely develop signs including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor immediately.

Since untreated mental/mood dilemmas (such as for example schizophrenia, schizoaffective disorders) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This medicine may pass into breast milk and possess undesirable effects on a nursing infant. Breast feeding is not recommended while taking clozapine. Consult your doctor before breast-feeding.

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