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Precautions

Do NOT use Methotrexate if:

• you happen to be allergic to your ingredient in Methotrexate
• you happen to be treating psoriasis or rheumatoid arthritis symptoms and you really are pregnant or breast-feeding
• you are treating psoriasis or rheumatoid arthritis symptoms and abuse alcohol or have liver problems, an immunodeficiency syndrome (eg, AIDS), bone marrow problems, or blood problems (eg, anemia, low white blood cell count, low platelet count)
• you've got moderate or severe kidney problems
• you consider acitretin.

Contact your physician or health care provider straight away if all of these sign up for you.

Some health conditions may connect to Methotrexate. Tell your physician or pharmacist if you have any medical ailments, particularly when any with the following connect with you:

• if you might be pregnant, planning to get pregnant, or are breastfeeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a good reputation for lung problems, defense mechanisms problems, neurological system problems (eg, seizures), liver problems (eg, hepatitis), or blood problems (eg, anemia, low white blood cells, low blood platelets)
• in case you have an active infection, severe vomiting or diarrhea, or dehydration
• in case you have mouth sores, excess fluid in your stomach or around your lungs, stomach or intestinal ulcers, bowel inflammation (eg, ulcerative colitis), or possibly a blockage of the stomach or bowel
• for those who have a folic acid deficiency, come in inadequate health, or use a good reputation for alcohol abuse
• if you happen to be receiving chemotherapy or radiation.

Some medicines may interact with Methotrexate. Tell your doctor in the event you take some other medicines, especially any of the following:

• Acitretin, azathioprine, etretinate, leflunomide, retinoids, or sulfasalazine for the reason that likelihood of liver problems could possibly be increased
• Chloramphenicol, corticosteroids (eg, prednisone), cyclosporine, dantrolene, hydantoins (eg, phenytoin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib), penicillin antibiotics, phenylbutazone, pristinamycin, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), tetracycline, or trimethoprim because they may increase the risk of Methotrexate's unwanted effects
• Folic acid or leucovorin given that they may decrease Methotrexate's effectiveness
• Digoxin because its effectiveness could possibly be decreased by Methotrexate
• Anticoagulants (eg, warfarin), cyclosporine, or theophylline because the chance of their unwanted effects could possibly be increased by Methotrexate.

This will not be a total set of all interactions that may occur. Ask your doctor if Methotrexate may interact along with other medicines which you take. Check with your physician before you begin, stop, or affect the dose of any medicine.

Important safety information:

• Methotrexate may cause drowsiness, dizziness, or blurred vision. These effects may be worse should you go on it with alcohol or certain medicines. Use Methotrexate with caution. Do not drive or perform other possibly unsafe tasks before you understand how you reply to it.
• Check with your physician when you are drinking alcoholic beverages if you are taking Methotrexate.
• Nausea, vomiting, and decrease of appetite are routine with Methotrexate. Ask your medical professional or pharmacist for solutions to decrease these effects if they occur.
• If vomiting or diarrhea occurs, you will need to adopt care not to become dehydrated. Contact your medical professional for instructions.
• Methotrexate may cause you to become sunburned quicker. Avoid the sun, sunlamps, or tanning booths until you recognize how you reply to Methotrexate. Use a sunscreen or wear protective clothing if you should be outside for greater than a short period of time.
• Methotrexate may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your physician if you have unusual bruising or bleeding. Tell a medical expert for those who have dark, tarry, or bloody stools.
• Methotrexate may lower the ability of your body to battle infection. Avoid contact with those who have colds or infections. Tell your medical professional in the event you notice signs of infection like fever, sore throat, rash, or chills.
• Do not receive a live vaccine (eg, measles, mumps) when you are taking Methotrexate. Talk with a medical expert when you get any vaccine.
• Men who take Methotrexate must always work with a condom when making love with a woman who may become pregnant. Do this as long as you adopt Methotrexate and for three months after you stop taking it.
• Do NOT take a lot more than the recommended dose or use more than prescribed without checking with your medical professional.
• Lab tests, including albumin levels, complete blood counts, and liver, lung, and kidney function, could be performed when you use Methotrexate. These tests could be used to monitor your problem or search for unwanted effects. Be sure to keep all doctor and lab appointments.
• Use Methotrexate with caution inside elderly; they might be more understanding of its effects.
• Methotrexate needs to be combined with extreme caution in youngsters younger than 2 years old; safety and effectiveness of these children are not confirmed.
• Pregnancy and breast-feeding: Methotrexate could cause birth defects and fetal and newborn death if you go on it when you are pregnant. Do not conceive if you are utilizing it. Use an effective kind of birth control method while you take Methotrexate and for at least 1 ovulatory cycle after you stop taking it. If you think you could be pregnant, contact your doctor straight away. Methotrexate is situated in breast milk. Do not breast-feed while taking Methotrexate.