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Uses

INDICATIONS

Indinavir can be an antiviral medication in the group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body. It is utilized to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.

INSTRUCTIONS

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Take indinavir the same manner it absolutely was prescribed in your case. Do not make medication in larger amounts, or get it for longer than recommended because of your doctor. Follow the directions in your prescription label.

This medication is sold with patient instructions for safe and effective use. Follow these directions carefully. Ask your physician or pharmacist when you have questions.
Take indinavir which has a full glass (8 ounces) of water or skim milk. You can also drink juice, coffee, or tea using this type of medication. Drink at least 6 glasses of water every day to stop kidney stones if you are taking indinavir. Indinavir must be taken on jail stomach, a minimum of 1 hour before or 2 hours after having a meal.

If you'd rather make medication with food, eat just a light meal, like dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is vital to work with indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medication is helping your problem, your blood will need to be tested frequently. Your liver function could also have to be tested. Do not miss any scheduled visits to a medical expert.

HIV/AIDS is normally treated with a combination of different drugs. To best treat your problem, utilize all of your respective medications as directed through your doctor. Be sure to look at medication guide or patient instructions furnished with each of the medications. Do not change your doses or medication schedule without advice from a medical expert. Every person with HIV or AIDS should remain within the good care of a physician.

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Take the missed dose when you remember and take your following dose in the regularly scheduled time. If you are over a couple of hours late in taking your indinavir, skip the missed dose and make next regularly scheduled dose. Do not take extra medicine to make the missed dose.

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DOSAGE

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Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis must be initiated immediately, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is probably the alternative regimens suited to nonoccupational postexposure HIV prophylaxis.

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Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should start promptly, preferably within 1 to 2 hours postexposure. The exact time period of therapy may vary based on the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.

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Dose Adjustments
Consider lowering the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence to the prescribed dose is crucial. Patients ought not customize the dose or discontinue therapy without consulting their physician.

Adequate hydration (1.5 liters/day) is essential during therapy to reduce potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could possibly be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

Store indinavir at room temperature far from moisture and warmth. Keep the capsules of their original container, combined with the packet of moisture-absorbing preservative that includes indinavir capsules.

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Side Effects

Get emergency medical help when you have these warning signs of a hypersensitivity: hives; lack of breath; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your medical professional simultaneously in case you have these serious negative effects:

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Less serious unwanted effects can include:

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This is not a complete list of side effects while others may occur. Tell your doctor about any unusual or bothersome side effect.

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Precautions

Do not take medicines if you're allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening unwanted side effects if you utilize them when you are taking indinavir.

Before taking indinavir, tell your medical professional should you be allergic to any drugs, or if you have:

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If you have these conditions, you will need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication could be damaging to an child. Tell your medical professional in case you are pregnant or prefer to become pregnant during treatment. HIV may be passed on the baby when the mother isn't properly treated when pregnant. Take all of the HIV medicines as forwarded to overcome your infection when you are pregnant.

Your name may have to be for auction on an antiviral pregnancy registry once you start using this medication.
You shouldn't breast-feed when you are using indinavir. Women with HIV or AIDS shouldn't breast-feed in any way. Even if your infant arrives without HIV, you might still pass herpes to the baby within your breast milk.

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