INDICATIONS
Indinavir is an antiviral medication in a very group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying inside you. It is utilized to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.
INSTRUCTIONS
Take indinavir exactly as it turned out prescribed for you personally. Do not consider the medication in larger amounts, or take it for over recommended from your doctor. Follow the directions in your prescription label.
This medication incorporates patient instructions for secure and efficient use. Follow these directions carefully. Ask your doctor or pharmacist in case you have any queries.
Take indinavir with a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea using this medication. Drink at the very least 6 servings of water daily to prevent kidney stones when you are taking indinavir. Indinavir should be taken on a clear stomach, at the very least an hour before or 2 hours following a meal.
If you want to consider the medication with food, eat merely a light meal, such as dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.
It is important to make use of indinavir regularly to have the most benefit. Get your prescription refilled before you run out of drugs completely.
To make certain medicines is assisting your condition, your blood will have to be tested regularly. Your liver function may also should be tested. Do not miss any scheduled visits to your physician.
HIV/AIDS is often treated having a combination of different drugs. To best treat your complaint, utilise all of the medications as directed because of your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not make positive changes to doses or medication schedule without advice from your physician. Every person with HIV or AIDS should remain underneath the good care of a health care provider.
Take the missed dose as soon as you remember and take the following dose with the regularly scheduled time. If you are greater than 120 minutes late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to generate up the missed dose.
DOSAGE
Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis needs to be initiated at the earliest opportunity, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is probably the alternative regimens suited to nonoccupational postexposure HIV prophylaxis.
Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should begin promptly, preferably within 1 to 2 hours postexposure. The exact time period of therapy may differ using the institution's protocol.
Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.
Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions
Strict adherence to the prescribed dose is crucial. Patients should not alter the dose or discontinue therapy without conferring with their physician.
Adequate hydration (1.5 liters/day) is essential during therapy to reduce the risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could possibly be necessary if nephrolithiasis occurs.
Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.
STORAGE
Store indinavir at room temperature away from moisture and warmth. Keep the capsules within their original container, along with the packet of moisture-absorbing preservative that comes with indinavir capsules.
Get emergency medical help in case you have some of these signs of a hypersensitive reaction: hives; lack of breath; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your doctor at the same time in case you have all of these serious side effects:
Less serious unwanted effects can sometimes include:
This is just not a complete set of unwanted side effects and others may occur. Tell your medical professional about any unusual or bothersome side-effect.
Do not take medicines in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening negative effects the use of them while you are taking indinavir.
Before taking indinavir, tell your doctor if you are allergic to the drugs, or in case you have:
If you've any of these conditions, you will need a dose adjustment or special tests to safely take indinavir.
FDA pregnancy category C. This medication might be harmful to an unborn baby. Tell your physician if you are pregnant or want to become pregnant during treatment. HIV might be passed towards the baby if the mother just isn't properly treated while pregnant. Take all of the HIV medicines as forwarded to overcome your infection while you are pregnant.
Your name may should be for auction on an antiviral pregnancy registry once you start using this medication.
You shouldn't breast-feed while you are using indinavir. Women with HIV or AIDS should not breast-feed in any way. Even if your baby arrives without HIV, you may still pass the herpes simplex virus towards the baby within your breast milk.
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