Baclofen is employed for treating spasm of skeletal muscles that create muscle clonus, rigidity, and pain due to multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to speak together. GABA released by some nerves causes the activity of other nerves to reduce. It is considered that Baclofen, acting like GABA, blocks the experience of nerves inside the area of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.
The usual starting dose of Baclofen for adults is 5 mg 3 x daily. Based on the response, the dose could be increased gradually every 72 hours to your maximum of 80 mg/day in numerous doses.
Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out from the reach of kids.
Baclofen could cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low hypertension, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
Use of Baclofen with drugs this depress the function of nerves can lead to additional reduction in brain function.
In addition towards the probability of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together might cause muscle weakness.
Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) can lead to greater depression of brain function as well as low blood pressure levels.
As Baclofen can increase blood glucose levels, doses of antidiabetic drugs should be adjusted when Baclofen is taken.
The usage of Baclofen by women that are pregnant is not evaluated.
Baclofen could be detected inside the breast milk of mothers taking oral Baclofen. No info is on the existence of Baclofen in the breast milk of mothers receiving Baclofen intrathecally.
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