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Baclofen can be used for treating spasm of skeletal muscles that cause muscle clonus, rigidity, and pain on account of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter within the brain. Neurotransmitters are chemicals that nerves use to talk collectively. GABA released by some nerves causes the experience of other nerves to lower. It is considered that Baclofen, acting like GABA, blocks the activity of nerves within the the main brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.

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The usual starting dose of Baclofen for adults is 5 mg 3 times daily. Based on the response, the dose may be increased gradually every three days to some maximum of 80 mg/day in a number of doses.

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Baclofen ought to be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen from the reach of children.

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Baclofen could potentially cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

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Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).

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Use of Baclofen with other drugs this depress the function of nerves may lead to additional decrease in brain function.

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In addition on the likelihood of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together might cause muscle weakness.

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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function and also low hypertension.

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As Baclofen can increase blood glucose levels, doses of antidiabetic drugs might need to be adjusted when Baclofen is taken.

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The use of Baclofen by expectant women will not be evaluated.

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Baclofen could be detected in the breast milk of mothers taking oral Baclofen. No information is on the presence of Baclofen inside breast milk of mothers receiving Baclofen intrathecally.

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