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Uses

INDICATIONS

Chloroquine is indicated for your suppressive treatment and then for acute attacks of malaria on account of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated to the management of extraintestinal amebiasis.

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INSTRUCTIONS

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Take chloroquine with meals or milk to reduce stomach upset, unless otherwise directed through your doctor.

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t is critical that you take chloroquine only as directed. Do not take much more of it, don't take on it often, and do not take on it much more time than your physician ordered. To do so could raise the possibility of serious side effects.

If you adopt chloroquine to keep you against getting malaria, keep taking it to the full time of treatment. If you already have malaria, you should still keep taking chloroquine for the full-time of treatment in case you begin to feel great right after days. This will help to increase infection completely. If you stop taking chloroquine too quickly, your symptoms may return.

Chloroquine works best once you go on the regular schedule. For example, in case you are to go on it once weekly to avoid malaria, it is advisable to go on it on the same day each week. Or in case you are to consider two doses every day, one dose may be taken with breakfast as well as the other with all the evening meal. Make sure which you usually do not miss any doses. If you've got any questions concerning this, seek advice from your quality of life care professional.

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If you miss a dose of chloroquine, go on it as quickly as possible. However, whether it is almost time for your next dose, skip the missed dose and get back on your regular dosing schedule. Do not double doses.

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DOSAGE 

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The dosage of chloroquine phosphate is frequently expressed when it comes to equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on a similar day of each week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body weight, but must not exceed the adult dose regardless of weight.

If circumstances permit, suppressive therapy should start two weeks ahead of exposure. However, failing this in grown-ups, an initial double (loading) dose of a single g (= 600 mg base), or even in children 10 mg base/kg could be consumed two divided doses, six hours apart. The suppressive therapy ought to be continued for eight weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of 1 g (= 600 mg base) as well as an additional 500 mg (= 300 mg base) after six to eight hours along with a single dose of 500 mg (= 300 mg base) on all of two consecutive days. This represents an overall total dose of 2.5 g chloroquine phosphate or 1.5 g base in 3 days.

The dosage for adults of low body mass and for infants and children must be determined as follows:

First dose: 10 mg base per kg (however, not exceeding just one dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding one particular dose of 300 mg base).

Third dose: (a day after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy by having an 8-aminoquinoline compound is essential.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, then 500 mg (300 mg base) daily for around 2-3 weeks. Treatment is usually combined with an effective intestinal amebicide.

STORAGE 

Store the medicine in the closed container at room temperature, faraway from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine don't needed.

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Side Effects

Along having its needed effects, a medicine might cause some unwanted effects. Although not many of these unwanted effects may occur, whenever they occur they might need medical attention. When chloroquine is employed for short amounts of time, negative effects tend to be rare. However, when it can be used for quite a long time and/or in high doses, unwanted effects are more inclined to occur and could be serious.

Check with your physician immediately if any of the following negative effects occur:
Less common

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Blurred vision
alternation in vision
eye pain
lack of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood and other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any loss in hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The side effects within the Less Common category above may also occur or get worse once you stop taking chloroquine.

Some negative effects may occur that usually usually do not need medical assistance. These unwanted effects may go away during treatment because your body adjusts to the medicine. Also, your quality of life care professional might be able to let you know about ways to stop or reduce some unwanted side effects. Check with your health care professional if the following unwanted side effects continue or are bothersome or if you have questions about them:

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Diarrhea
difficulty in seeing to read
headache
itching (more widespread in black patients)
loss in appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside of mouth
skin rash

Other side effects not listed may also appear in some patients. If you notice another effects, talk with your doctor.

Precautions

If you'll be taking chloroquine for quite a while, it is critical that your medical professional check you at regular visits for virtually any blood problems or muscle weakness that may be brought on by chloroquine. In addition, talk with your medical professional immediately if blurred vision, difficulty in reading, or another difference in vision occurs during or after treatment. Your doctor might prefer you to definitely have your eyes checked by an ophthalmologist (eye doctor).

If your symptoms do not improve in just a week or when they become worse, talk with a medical expert.

Make sure you know how you react to chloroquine before you decide to drive, use machines, or do anything whatsoever else that might be dangerous should you be not able to see well.

Chloroquine may cause blurred vision, difficulty in reading, or other alternation in vision. It could also cause a lot of people being lightheaded.

If these reactions are especially bothersome, talk with your physician.

Certain medicines shouldn't be used at or around the time of consuming food or eating some kinds of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions that occurs. Discuss along with your medical practioner the use of your medicine with food, alcohol, or tobacco.

There aren't any adequate and well-controlled studies evaluating the protection and efficacy of chloroquine in expectant women. Usage of chloroquine during pregnancy should be avoided except inside suppression or management of malaria when within the judgment from the physician the benefit outweighs the possible risk towards the fetus.

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