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This combination medication is used to take care of signs of Parkinson's disease or symptoms that are parkinson-likesuch as shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a substance that is naturally occurringdopamine) within the brain. Levodopa modifications into dopamine in mental performance, assisting to control movement. Carbidopa stops the breakdown of levodopa in the bloodstream therefore more levodopa can enter the brain. Carbidopa can additionally reduce some of levodopa's part effects such as vomiting and nausea.

How to use Sinemet

Take this medication by mouth with or without food as directed by the doctor, often 3 to 4 times a day.

Taking this medication with food might help to decrease nausea. It is best to avoid a high-protein diet (it decreases the amount of levodopa that your body takes in) during therapy, unless directed otherwise by the doctor. Separate your dosage of the medication by since hours that are many possible from any iron supplements or products containing iron (such as multivitamins with minerals) you may take. Iron can reduce the amount of this medication absorbed by the body. Consult your pharmacist or doctor for lots more details.

The dosage is situated on your condition that is medical and to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a dose that is low gradually increase your dose. Follow your physician's guidelines carefully. This combination medication comes in different strengths with different amounts of levodopa and carbidopa in each tablet. Be sure you have the correct strength of both drugs. Your doctor might also alone prescribe carbidopa to be used with this combination.

Make use of this medicine regularly to get the benefit that is most from it. Each day to help you remember, take it at the same times.

Some clients may experience a "wearing-off" (worsening of symptoms) before the next dose is due. An "on-off" effect may also happen, in which unexpected short periods of stiffness occur. If these effects occur, contact your medical professional for possible dosage adjustments which could help to lessen this effect.

Do not stop taking this medication without consulting your medical professional. Some conditions may become worse when this medication is quickly reduced or suddenly stopped. Your dose may gradually need to be reduced. (See also negative effects part.)

Tell your physician if your condition will not enhance or if it worsens.

Side Effects

Dizziness, lightheadedness, nausea, vomiting, loss of appetite, difficulty sleeping, uncommon dreams, or headache may happen. If any of these effects persist or worsen, tell your pharmacist or doctor promptly.

This medication may cause saliva, urine, or sweat to turn a dark color. This effect is safe, but your clothes can be stained.

To lessen the risk of dizziness and lightheadedness, get up slowly when increasing from a sitting or position that is lying.

Remember that your doctor has prescribed this medicine she has judged that the benefit to you is greater than the risk of adverse effects because he or. Many people using this medication do not have side that is serious.

Some individuals taking this medication have dropped asleep instantly throughout their usual activities that are dailysuch as talking on the phone, driving). In some full instances, sleep occurred without any feelings of drowsiness beforehand. This sleep impact may occur anytime during treatment with carbidopa/levodopa regardless if you purchased this medication for a time that is long. Until you have discussed this effect with your doctor if you experience increased sleepiness or fall asleep during the day, do not drive or do other possibly dangerous activities. Your danger with this sleep impact is increased by making use of alcohol or other medicines that will allow you to drowsy. See also Precautions section.

Inform your doctor straight away you can't control/spasms, greatly increased eye blinking/twitching, fainting, vision changes (such as blurred vision, double vision), eye pain, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds, mental/mood changes (such as agitation, hallucinations, depression, thoughts of suicide), signs of infection (such as sore throat that doesn't go away), easy bleeding/bruising, unusual tiredness, tingling of the hands/feet, unusual strong urges (such as increased gambling, increased sexual urges) if you have any serious adverse effects, including: new/worsening movements.

Get medical help right away if you have any very severe side effects, including: upper body pain.

Abruptly stopping or reducing the dose of this medicine may seldom cause a very condition that is serious neuroleptic malignant syndrome (NMS). Get medical help straight away for those who have any of the following symptoms: fever, uncommon muscle tissue stiffness, severe confusion, sweating, fast/irregular heartbeat, rapid breathing.

an extremely serious allergic reaction to this drug is rare. However, get medical help right away if you notice any outward symptoms of a significant sensitive reaction, including: rash, itching/swelling (especially associated with the face/tongue/throat), severe dizziness, difficulty breathing.

This is not a list that is complete of adverse effects. If you notice other effects not listed above, contact your pharmacist or doctor.

In the US -

Phone your physician for medical advice about negative effects. You may possibly report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about part impacts. You may report effects that are side Health Canada at 1-866-234-2345.


Before using this medicine, tell your doctor or pharmacist in the event that you have any other allergies if you are allergic to carbidopa or levodopa; or. This product may contain ingredients that are inactive which can cause allergic reactions or other problems. Talk to your pharmacist for lots more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, glaucoma, breathing issues (such as asthma), heart disease (such as coronary arrest, irregular heartbeat), kidney disease, stomach/intestinal ulcer, mental/mood disorders (such as for example depression, schizophrenia), blood problems, seizures, rest disorders.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. See also Side Results part.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and natural products).

During pregnancy, this medication should be used only once obviously needed. Discuss the risks and benefits with your physician.

Levodopa passes into breast milk. Its unknown if carbidopa passes into breast milk. Consult with your medical practitioner before breast-feeding.

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