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NOOTROPIL is indicated for patients suffering from myoclonus of cortical origin, regardless of aetiology, and really should be utilized in combination with other anti-myoclonic therapies.
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The dosage regime shows important interindividual variability, requiring an individualised dose finding approach. A reasonable protocol would be to introduce piracetam in a dosage of 7.2 g/day, increasing by 4.8 g/day every three or four days up to a maximum of 20g/day, succumbed either two or three divided doses and other antimyoclonic drugs unchanged at their optimal dosage. If possible, based on clinical benefit, an attempt needs to be designed to subsequently decrease the dosage of other antimyoclonic drugs.
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Store this medicine at room temperature inside a tightly-closed container, faraway from heat and lightweight.
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The unwanted effects reported associated with Nootropil include nervousness, agitation, irritability, anxiety and sleep disturbances. The incidence of these during clinical trials was 5% or less and they also were more often noted in the older patients taking greater than 2.4 g daily. In the majority of cases a dose reduction sufficed to create these symptoms disappeared. Some patients may complain of fatigue or drowsiness. Gastro-intestinal problems including nausea, vomiting, diarrhoea and stomachache have also been reported, on the other hand Incidence during clinical trials was 2% or less. Other symptoms, for example vertigo, headaches, trembling and sexual stimulation have occasionally been reported.
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NOOTROPIL (Piracetam) is contra-indicated in patients with severe renal impairment (renal creatinine clearance of lower than 20 ml per minute), hepatic impairment and to those under 16 years old. It is also contraindicated in patients with cerebral haemorrhage, Huntington's Chorea as well as in those with hypersensitivity to piracetam, other pyrrolidone derivatives or the excipients .
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