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ARAVA is indicated in adults to the treatment of active rheumatism (RA):


Take this medicine only as directed through your doctor. Do not take more of it, do not take it more frequently, and do not take on it a bit longer than your doctor ordered.

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The dose on this medicine will change for different patients. Follow a medical expert's orders or perhaps the directions around the label. The following information includes merely the average doses on this medicine. If your dose is unique, tend not to change it unless your medical professional informs you to do so.

The level of medicine that you just take depends for the strength of the medicine. Also, the volume of doses you are taking on a daily basis, the time allowed between doses, and also the time period you adopt the medicine depend about the problem that you are using the medicine.

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For oral dosage form (tablets):

For rheumatoid arthritis:

If you miss a dose of this medicine, get it as soon as possible. However, if it is almost time for your forthcoming dose, skip the missed dose and return to your family dosing schedule. Do not double doses.

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Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light. Keep out with the reach of kids. Do not keep outdated medicine or medicine no more needed. Store the medicine inside a closed container at room temperature, far from heat, moisture.

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 Keep out from the reach of children. Do not keep outdated medicine or medicine no longer needed. Store the medicine inside a closed container at room temperature, far from heat, moisture.


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Side Effects

Stop by using this medicine and check with a medical expert right away if you're having burning, numbness, tingling, or painful sensations inside arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions for this utilization of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

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Along having its needed effects, medicines could potentially cause some unwanted side effects. Although not many of these negative effects may occur, whenever they occur they will often need medical help.

Check with a medical expert immediately if any from the following unwanted side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
lack of appetite
nausea / vomiting
sore throat
tightness inside the chest
yellow eyes or skin
Less common
Burning feeling in the chest or stomach
burning, prickling, or tingling sensation inside the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
difficulty breathing
tenderness in the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood inside stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling around the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
small of the back or side pain
pains in the stomach, side, or abdomen, possibly radiating towards the back
pale skin
pinpoint red spots for the skin
rapid, shallow breathing
red lesions on the skin, often with a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or about the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness in the arms, hands, legs, or feet

Some side effects may occur very often tend not to need medical attention. These unwanted side effects might go away during treatment since your body adjusts on the medicine. Also, your wellbeing care professional might be able to let you know about methods to prevent or reduce a few of these unwanted side effects. Check with your health care professional if any with the following side effects continue or are bothersome or if you have any queries about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching from the skin
pain or burning inside the throat
runny nose

Other unwanted effects not listed can also appear in some patients. If you notice any other effects, check along with your medical practioner.



It is essential that your medical professional look at the progress at regular visits to ensure that this drugs are working properly. Blood tests may be needed to evaluate for uncomfortable side effects.

Using this medicine if you are pregnant may damage your developing fetus. Use an effective form of contraceptive to help keep from getting pregnant. If you think you might have conceive while using the medicine, tell your doctor right away.

Leflunomide could also cause birth defects if your father is utilizing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as being a kind of contraception during intercourse. A man planning to father a young child should stop taking this medicine and look with his doctor immediately.

Serious skin reactions can occur using this type of medicine. Stop applying this medicine and look with your medical professional straight away if you have any in the following symptoms while taking this medicine: blistering, peeling, or loosening from the skin; chills; itching; joint or muscle pain; red skin lesions, often having a purple center; sores, ulcers, or white spots within the mouth or for the lips; or unusual tiredness or weakness.

Liver problems may occur while you are using this medicine. Stop using this medicine and look with a medical expert right away if you're having several of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss in appetite; nausea or vomiting; skin rash; swelling with the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the volume of white blood cells with your blood, helping the potential for getting disease. It can also lower the quantity of platelets, that are required for proper blood clotting. If this occurs, there are particular precautions it is possible to take, particularly when your blood count is low, to lessen the risk of infection or bleeding:

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Check with your physician without delay if you've got a cough with or without nausea, breathlessness, or any difficulty with breathing.

You needs to have a skin test for tuberculosis before starting employing this medicine. Tell a medical expert in case you or anyone with your home has ever had a good reaction to a tuberculosis test.

Using this medicine may increase your chance of getting serious infections or cancer. Talk to your doctor if you've got concerns about it risk.

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Do not take other medicines unless they've been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamins.

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